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Abstracts |

The Effect of Hypercalcemia on Acid-base Metabolism in Man.

H. O. Heinemann, M.D.
Ann Intern Med. 1963;58(4):741. doi:10.7326/0003-4819-58-4-741_3
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It is well established that hypercalcemia has profound effects on various renal functions. Less well known is that elevation of the serum calcium concentration may also affect acid-base metabolism. Balance studies and acute experiments were performed in 10 patients with hypercalcemia secondary to neoplastic disease. The results indicate that prolonged hypercalcemia leads to 2 distinct derangements in acid-base metabolism, which at present cannot be correlated. First, metabolic alkalosis, characterized by elevation of the carbon dioxide content and pH of arterial blood. The alkalosis cannot be ascribed to bone destruction and resulting release of buffer base, nor is it due to


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