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Is Oxytocin the Diurnal Regulator of Renal Hemodynamics?

C. Ezrin, M.D.; L. W. Loach, M.D.; S. Neiman, M.D.; M. Barkin, M.D.; and T. F. Nicholson, M.B.
Ann Intern Med. 1963;58(4):742. doi:10.7326/0003-4819-58-4-742_1
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A reversed diurnal excretory rhythm of water, creatinine, and electrolytes was observed in a woman with fluid retention that first appeared after a head injury. Synthetic oxytocin produced a diuresis and restored a normal excretory rhythm. Recumbency for 24 hours also induced a return to normal rhythm. Spontaneous resumption of a normal cycle of renal excretion, even when the patient continued to be up and about during the day, was sometimes observed 1 day before menstruation.

Inulin, PAH, and endogenous creatinine clearance studies showed that oxytocin and recumbency increased the daytime GFR (glomerular filtration rate). In the isolated, perfused dog


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