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Abstracts |

Oxalate Metabolism.

L. H. Smith Jr., M.D.
Ann Intern Med. 1963;58(4):743. doi:10.7326/0003-4819-58-4-743_2
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Oxalate is one of the most common constituents of kidney stones. Ingested oxalate is poorly absorbed, the majority of that appearing in the urine representing a metabolically formed end-product. Primary hyperoxaluria is a rare but serious disorder in which there is overproduction of oxalate with recurrent nephrolithiasis, nephrocalcinosis, and, occasionally, widespread tissue deposition of calcium oxalate, termed oxalosis. Previous studies have demonstrated that glycine and ascorbic acid are oxalate precursors. Recent studies have shown impaired metabolism of glyoxylate-C14 in hyperoxaluria with increased incorporation of the isotope into urinary oxalate and glycolate. Glycolic aciduria has been demonstrated as a biochemical manifestation



metabolism ; oxalates

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