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Abstracts |

Some Observations on Renal Function before and after Correction of Hypercalcemia.

H. Lovice, M.D.; and T. B. Connor, M.D.
Ann Intern Med. 1963;58(4):744-745. doi:10.7326/0003-4819-58-4-744_4
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Twenty patients with hypercalcemia had creatinine clearances (Ccr) and urine concentration tests performed before and after correction of this abnormality. These measurements were repeated at multiple intervals from 1 week to 5 years following correction of hypercalcemia. Fifteen patients had surgically proven hyperparathyroidism, and in 5 patients the hypercalcemia was corrected as follows: thyrotoxicosis (1), RAI therapy; lung cancer (1), supervoltage radiotherapy; myeloma (2) and sarcoidosis (1), prednisone therapy.

Prior to correction of their hypercalcemia, 7 of 15 patients with hyperparathyroidism had reduced Ccr (mean Ccr 53 ml/minute) and mean serum calcium of 13.9 mg/100 ml. Mean serum calcium in


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