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Acute Pericarditis due to Histoplasma Capsulatum

Ann Intern Med. 1963;58(5):862-867. doi:10.7326/0003-4819-58-5-862
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Skin sensitivity to Histoplasma capsulatum in patients with pericardial calcification was first reported in 1955 by Billings and Couch (1). They described 2 patients with pericardial calcifications, positive histoplasmin skin tests, and negative reactions to tuberculin. Neither patient had a past medical history suggestive of acute pericarditis, and the presumptive diagnosis was chronic calcific pericarditis secondary to histoplasmosis. Several similar patients (2-7) have since been reported, and in some (4-7) there was clinical evidence that the pericarditis was constrictive in nature.

Acute pericarditis attributed to H. capsulatum has been adequately documented in only 7 patients. In 1958, Heiner (8) reported


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