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Etiology of Bacterial Endocarditis: Before and Since the Introduction of Antibiotics

Ann Intern Med. 1963;58(6):946-952. doi:10.7326/0003-4819-58-6-946
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Since the introduction of antimicrobial agents into clinical medicine, many significant changes have been noted in certain aspects of infectious diseases. These drugs have favorably affected the occurrence, natural history, clinical course, and the mortality, as well as the morbidity, of some of the specific bacterial infections. Also, definite changes have been impressively demonstrated by Finland and others concerning the alteration in the causative bacterial flora of such infections as meningitis, empyema, septicemia, and terminal pneumonia (1, 2). Though it is generally assumed that the causative organisms of endocarditis are also changing, this impression can only be supported by the


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