1 June 1963, Vol 58, No. 6>

Email

American College of Physicians

You must be logged in as an individual user to share content.

Copyright in the material you requested is held by American College Of Physicians (unless otherwise noted). This email ability is provided as a courtesy, and by using it you agree that that you are requesting the material solely for personal, non-commercial use, and that it is subject to ACP's Conditions of Use. The information provided in order to email this topic will not be used to send unsolicited email, nor will it be furnished to third parties. Please refer to American College Of Physicians's Privacy Policy for further information.

Copyright © American College Of Physicians. All rights reserved.
Share
Get Citation

VICTOR HERBERT, RALPH ZALUSKY, CHARLES S. DAVIDSON; Correlation of Folate Deficiency with Alcoholism and Associated Macrocytosis, Anemia, and Liver Disease. Annals of Internal Medicine. 1963 Jun;58(6):977-988.

Download citation file:

RIS (Zotero)

EndNote

BibTex

Medlars

ProCite

RefWorks

Reference Manager

Copyright © 2013 The American College of Physicians. All Rights Reserved.
PDF

Articles | 1 June 1963

Correlation of Folate Deficiency with Alcoholism and Associated Macrocytosis, Anemia, and Liver Disease

VICTOR HERBERT, M.D.; RALPH ZALUSKY, M.D.; and CHARLES S. DAVIDSON, M.D., F.A.C.P.

Ann Intern Med. 1963;58(6):977-988. doi:10.7326/0003-4819-58-6-977

Text Size: A A A

Article

References

Comments

Macrocytosis has been observed frequently in association with cirrhosis since 1884 (1). The concomitant presence of macrocytosis, anemia, and cirrhosis, usually in association with alcoholism, sometimes with a macronormoblastic or even a megaloblastic bone marrow, has been frequently noted in the medical literature (2-10).

In 1938, noting no correlation between macrocytosis and severity of liver damage, Bianco and Jolliffe (2) concluded: "In view of these findings we are inclined to regard the macrocytosis of the alcohol addict not as a manifestation of inability on the part of the liver to store a hematopoietic principle, but as an extrinsic deficiency of

Sign In

Forgot Your Password?

Buy This Article

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

First Page Preview

View Large

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).

Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.

All you need to read in the other general jounals
BMJ 2010;341:c5893-c1494.

Comments

Please read the other comments before posting. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discretion of The American College of Physicians editorial staff. Please be sure your email address is updated in your account, otherwise the American College of Physicians will not be able to contact you about your comment.

* = Required Field

Comment Author(s)* (if multiple authors, separate names by comma)

Example: John Doe

Affiliation & Institution*

Disclosure of Any Conflicts of Interest* (applies to the past 5 years and foreseeable future) Indicate any potential conflicts of interest of each author below, including specific financial interests and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript (eg, employment/affiliation, grants or funding, consultancies, honoraria, speakers bureau, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents filed, received, or pending). If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.

Please disclose any conflicts of interest or check the box below.

No potential conflicts or relevant financial interests

Comment Title*

Comment*

Get Audio Code

Submit Cancel

Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.