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Experimental Pyelonephritis and Hypertension: Implications for the Clinical Problem

Ann Intern Med. 1963;59(1_Part_1):37-52. doi:10.7326/0003-4819-59-1-37
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The relationships between pyelonephritis and hypertension in man have been debated since the studies of Longcope (1) and of Weiss and Parker (2). These investigators demonstrated that chronic pyelonephritis frequently was associated with hypertensive vascular disease and was seen in patients with accelerated nephrosclerosis in an especially high incidence. Perhaps particularly because these observations were made during an era of increasing concentration on the role of the kidney in the production of hypertension, it rapidly and generally was assumed that chronic pyelonephritis was an important primary cause. Subsequently, opinions about the relative etiologic importance of pyelonephritis in hypertension have ranged


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