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Treatment of Adrenocortical Cancer with O,P′-DDD

ANTONIO DA SILVA COELHO NETTO, M.D.; BERNARDO LÉO WAJCHENBERG, M.D.; CASSIO RAVAGLIA, M.D.; VIRGILIO GONÇALVES PEREIRA, M.D.; JOSÉ SHNAIDER, M.D.; ARMANDO AGUIAR PUPO, M.D.; and ANTONIO BARROS DE ULHOA CINTRA, M.D., PH.D.
Ann Intern Med. 1963;59(1_Part_1):74-78. doi:10.7326/0003-4819-59-1-74
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The initial observations of Nelson and Woodward (1, 2) that the feeding of the insecticide, 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane (DDD) to dogs results in necrosis and atrophy of the adrenal cortex opened a new research field for adrenocorticolytic drugs. Brown et al. (3-5) observed that necrosis of the adrenal cortex was followed by a decrease in urinary excretion of 17-hydroxycorticosteroids. In these animals a picture compatible with adrenocortical insufficiency developed which was not modified by the simultaneous administration of adrenocorticotropic hormone (ACTH) but which could be prevented by cortisone.

Other authors (6-8) confirmed these initial data and the technical grade DDD

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