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Wegener's Granulomatosis: A Clinico-pathologic Study of Four Cases

Ann Intern Med. 1963;59(4):521-530. doi:10.7326/0003-4819-59-4-521
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Wegener's granulomatosis is a rare disease characterized by necrotizing, granulomatous lesions of the respiratory system, disseminated arteritis, and terminal glomerulonephritis (1). The syndrome was first reported by Klinger in 1931 (2). Wegener's reports of "rhinogenous granuloma" appeared in 1936 and 1939 (3, 4). In 1961, Lansdown reported 51 confirmed cases (5). The following 4 case reports are presented to illustrate the features of the disease and its similarity to periarteritis nodosa, rheumatoid arthritis, and anaphylactoid purpura.

CASE REPORTS: CASE 1R. G., a 25-year-old plaster-finisher, was admitted to the Minneapolis Veterans Hospital, January 12, 1949. Six weeks earlier he had


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