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Hypercalcemia in Patients with Malignant Lymphoma

Ann Intern Med. 1963;59(4):531-536. doi:10.7326/0003-4819-59-4-531
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Hypercalcemia is a serious complication of primary or secondary neoplastic bone disease. Most commonly, hypercalcemia occurs in neoplasms of the breast, lung, kidney (1), and multiple myeloma (2). Several cases of hypercalcemia in patients with lymphomatous disease have been reported (1, 3-5). However, this metabolic aberration in patients with malignant lymphoma has not received the emphasis in the literature that it might merit in view of its incidence.

In this communication, a series of 29 patients with malignant lymphoma and tumorous bone involvement, hypercalcemia, or both, are reported. Changes in serum calcium, phosphorus, and alkaline phosphatase levels, and in roentgenographic


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