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Laboratory and Clinical Studies of Gentamicin: A New Broad-spectrum Antibiotic

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Copyright ©, 1963, by The American College of PhysiciansThe American College of Physicians

Ann Intern Med. 1963;59(5_Part_1):593-604. doi:10.7326/0003-4819-59-5-593
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Gentamicin* is a new broad-spectrum antibiotic that offers promise in the treatment of infections caused by a wide variety of gram-negative rods. It is an antibiotic mixture of two isomers that share the same antibacterial and pharmacologic principles (1) and that has been isolated by Weinstein and coworkers (2) from two previously undescribed microorganisms of the genus Micromonospora. These two species are called Micromonospora pupurea n. sp. and Micromonospora echinospora n. sp. Gentamicin has been extensively investigated in our laboratory and in a number of patients, several of whom received careful pharmacologic studies at the Clinical Research Center of the


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