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Patterns of Polymyositis and Their Responses to Treatment

Ann Intern Med. 1963;59(6):827-838. doi:10.7326/0003-4819-59-6-827
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Polymyositis encompasses a group of disorders, of unknown cause, in which muscular weakness is the principal clinical feature. They are the most common primary myopathies that begin in adult life. Pathologically degenerative and inflammatory changes are found in the muscles in these conditions (1), while the most characteristic clinical laboratory finding is an elevation of serum enzymes such as serum glutamic oxaloacetic transaminase or serum glutamic pyruvic transaminase, aldolase, creatine phosphokinase, lactic dehydrogenase, and other enzymes that normally reside within the muscle fibers. These are apparently released during the disease process and serve both as helpful tools for diagnosis and




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