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Seronegative and Seropositive Rheumatoid Arthritis: Clinical, Radiological, and Biochemical Differences

Ann Intern Med. 1964;60(1):88-94. doi:10.7326/0003-4819-60-1-88
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The majority of patients with rheumatoid arthritis diagnosed according to the American Rheumatism Association criteria (1) have positive latex or sensitized sheep cell agglutination tests (seropositive); the remainder have negative tests (seronegative). There are certain characteristics and correlations in respect to seropositivity (2, 3). Most patients with subcutaneous nodules are in the seropositive group. Vasculitis is more common in patients with strongly positive agglutination reactions; positive reactors more frequently exhibit positive lupus erythematosus cell preparations. Splenomegaly and lymphadenopathy are more frequent in seropositive patients. Latex or sheep cell agglutination tests, positive when rheumatoid arthritis is first diagnosed, usually remain positive.


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