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Epidemic Coxsackie Virus Infection with Mixed Clinical Manifestations

Ann Intern Med. 1964;60(2_Part_1):196-203. doi:10.7326/0003-4819-60-2-196
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Webster defines epidemic as "common to, or affecting at the same time, many in a community" (1). Classically, epidemic infectious disease is recognized when a clinical syndrome occurs common to all affected persons. Thus, epidemics caused by measles, influenza, and smallpox viruses are readily recognized and distinguished from one another on clinical grounds. However, a single agent is not always implicated in epidemic infections with homogeneous clinical manifestations. Such situations have been encountered with increasing frequency during studies of epidemic "poliomyelitis." Johnson, Shuey, and Buescher (2) found at least seven different enteroviruses associated with paralytic and nonparalytic CNS disease occurring


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