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Cardiac Amyloidosis: Clinical Studies of 24 Cases.

Paul L. Bleakley, M.D.; and Paul N. Yu, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):316. doi:10.7326/0003-4819-60-2-316_2
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Clinical and pathologic studies were made in 24 cases of cardiac amyloidosis. The patients were divided into two groups. Group I patients consisted of 10 elderly males with interstitial deposition of amyloid confined to enlarged hearts (460 to 650 g). Group II patients included 14 patients who had variable heart size (216 to 660 g) and generalized amyloidosis with predominantly nodular and perivascular deposits of amyloid in the myocardium.

Congestive heart failure was observed in 6 patients of Group I and in 10 patients of Group II. Hypotension and albuminuria were common in Group II but infrequent in Group I.


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