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Metabolic Effects of Diuretic and Nondiuretic Benzothiadiazines.

William R. Wilson, M.D., F.A.C.P.; Daniel B. Stone, M.D.; Ronald Okun, M.D.; and R. Patterson Russell, M.D.
Ann Intern Med. 1964;60(2_Part_1):317. doi:10.7326/0003-4819-60-2-317_1
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A double-blind study of the metabolic effects of trichlormethiazide (TCZ) and diazoxide was performed in 45 hypertensive patients. Each patient received TCZ, 8 mg/day for 3 weeks, then was randomly allocated to one of three groups for 4 weeks. Fifteen patients received TCZ, 8 mg/day (group I); 15 patients received TCZ, 8 mg plus diazoxide, 200 mg, daily (group II); 15 patients received TCZ, 8 mg plus diazoxide, 400 mg, daily (group III). Two-hour postprandial blood sugars (PPBS), serum urea nitrogen (SUN) and serum uric acid (SUA) were measured before and after the trial.

"Thiazide hyperglycemia" developed in 17 patients;


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