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Triamterene and Hydrochlorothiazide in the Treatment of Hypertension.

William C. Heath, M.B., B.S.; and Edward D. Freis, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):317. doi:10.7326/0003-4819-60-2-317_2
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The pteridine diuretic triamterene, 100 mg twice daily, did not alter the urinary potassium excretion control values when given to seven nonedematous inpatients. In view of the saluretic potency of the benzothiadiazines and the potassium sparing action of triamterene, a combination of the two drugs was evaluated in 13 patients on a controlled sodium intake. Sodium excretion averaged 154 mEq/24 hr during control; 332 with hydrochlorothiazide, 50 mg, twice daily; and 341 mEq/24 hr with hydrochlorothiazide, 25 mg plus triamterene 50 mg, twice daily. Potassium increased from 60 to 80 mEq/24 hr with hydrochlorothiazide but decreased to 50 mEq with


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