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Pathology of the Cardiac Conduction System in Hemochromotosis.

Thomas N. James, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):317-318. doi:10.7326/0003-4819-60-2-317_3
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Cardiac involvement by hemochromatosis is one of the well-known manifestations of this disease, and atrial arrhythmias and heart block are commonly observed. This is a report of the pathology of the cardiac conduction system in four patients with hemochromatosis who developed atrial arrhythmias or heart block.

The blood supply to the sinus node and atrioventricular (A-V) node was carefully dissected in each case. Subserial sections of both nodes were prepared for microscopic study with the Goloner trichrome stain and Gomori's iron reaction.

In all four hearts the fibers of the A-V node contained large amounts of iron and exhibited focal


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