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Abstracts |

Serum Creatine Phosphokinase (CPK) Activity in Disorders of Heart and Skeletal Muscle.

Joseph W. Hess, M.D.; and R. P. MacDonald, Ph.D.
Ann Intern Med. 1964;60(2_Part_1):318. doi:10.7326/0003-4819-60-2-318_2
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Serum enzyme determinations that are commonly available in hospital laboratories for aid in the diagnosis of diseases of the heart and skeletal muscle lack tissue specificity. Thus, it may be difficult to interpret elevated serum glutamic oxaloacetic transaminase (SGOT) and lactate dehydrogenase (LDH) activities in a patient suspected of having had an acute myocardial infarction, but who also has hepatic congestion, active liver disease, or has had a recent episode of shock. Likewise, patients with disorders that involve multiple tissue types including skeletal muscle may have elevated serum enzyme levels, but the relative contribution of the various organs cannot be


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