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"Impending" Myocardial Infarction: Is Anticoagulant Drug Therapy Valuable?

Arthur M. Master, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):321. doi:10.7326/0003-4819-60-2-321_1
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"Impending" myocardial infarction may present varying clinical pictures. This study deals with a group of patients in whom the syndrome was characterized by a sudden change in symptomatology. Where angina pectoris pre-existed, there developed increasing frequency, severity, and duration of chest pain or pressure. Precipitating factors were more minor and response to nitroglycerin less satisfactory. Also included were a few persons previously asymptomatic who suddenly developed repeated attacks of angina pectoris. Cases of "acute coronary insufficiency without occlusion" and other variants of the "impending" phase, such as single or repeated episodes of prolonged and severe chest pressure, were not part


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