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Augmented Natriuretic Response to Acute Sodium Infusion Following Blood Pressure Elevation with Metaraminol in Normotensive Subjects.

Carlos A. Vaamonde, M.D.; Ruben G. Lancestremere, M.D.; Solomon Papper, M.D., F.A.C.P.; I. Norman Sporn, M.D.; and Joseph L. Belsky, M.D.
Ann Intern Med. 1964;60(2_Part_1):321. doi:10.7326/0003-4819-60-2-321_2
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It is well-established that patients with essential hypertension have an exaggerated natriuresis in response to acute intravenous administration of sodium. While the mechanism for this remains unknown, one of the possibilities is that elevation of blood pressure per se may cause this enhanced natriuresis.

Five normotensive male subjects were studied. Three received a diet containing 150 mEq of sodium daily and 2 a diet containing 10 mEq daily. They remained recumbent from 8:00 AM until 3:00 PM and voided spontaneously at 30 minute intervals. The subjects were studied on four separate occasions. (1) "Blank day"; no manipulation was undertaken other


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