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Production of Hypercholesterolemia and Atherosclerosis in Rabbits by a Diet Rich in Shellfish.

William E. Connor, M.D., F.A.C.P.; Jay J. Rohwedder, M.D.; and John C. Hoak, M.D. (Associate)
Ann Intern Med. 1964;60(2_Part_1):321-322. doi:10.7326/0003-4819-60-2-321_3
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Because the fat content of sea food is largely polyunsaturated, fish and shellfish are commonly recommended in diets designed to reduce serum cholesterol levels and to treat atherosclerosis in man. Eighteen recently published articles and books, without exception, stress the preferential use of fish and shellfish in diets for the treatment of coronary heart disease. Yet the effect on lipid metabolism and atherosclerosis from feeding the flesh of sea food to humans or animals is not known.

Rabbits were fed pellets containing a mixture of shrimp and Purina chow for 24 weeks and then autopsied. The serum lipids were determined


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