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Abstracts |

Response of the Vascular System to Norepinephrine in Man After Oral Administration of Guanethidine.

Gerhard H. Muelheims, M.D.; Richard W. Entrup, M.D.; Donald Paiewonsky, M.D.; and Donald S. Mierzwiak, M.D.
Ann Intern Med. 1964;60(2_Part_1):322. doi:10.7326/0003-4819-60-2-322_1
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Six healthy male subjects received a constant infusion of norepinephrine bitartrate at a concentration of 2 µg/min of the base that was then increased to 4 µg/min, 8 µg/min, 15 µg/min, and 20 µg/min. Each infusion period lasted 4 minutes. The blood pressure and electrocardiogram were determined at 2 and 4 minute intervals. The subjects then received 200 mg of guanethidine by mouth on the first day and 100 mg guanethidine on each of the 2 following days. The infusion of norepinephrine was repeated on the fourth day.

The preguanethidine infusion of norepinephrine elicited in all subjects a rise in

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