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Alcoholic Fatty Infiltration of the Liver; Diagnostic and Therapeutic Problem.

Robert E. Dye, M.D.; Graham H. Jeffries, M.R.C.P.; and Marvin H. Sleisenger, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):325. doi:10.7326/0003-4819-60-2-325_1
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Acute fatty infiltration of the liver presents a challenging problem. It is our purpose to report a series of patients whose presenting complaints and course seemed to fit a characteristic clinical pattern. The initial clinical impression was usually primary or secondary malignant biliary-tract disease. Hepatitis or cirrhosis—acute fatty infiltration being rarely considered. Fatty infiltration was established in most patients by needle biopsy of the liver, at laparotomy, or at necropsy. The series comprised 42 patients, two thirds of them female who were predominantly middle-aged with massive hepatomegaly and a symptom complex that included anorexia, fever, weight loss, nausea, vomiting, and




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