The full content of Annals is available to subscribers

Subscribe/Learn More  >
Abstracts |

Pathophysiology of Endotoxin Shock.

Robert P. Gilbert, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):327. doi:10.7326/0003-4819-60-2-327_3
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

The hypotension that is produced in various mammalian species by the administration of gram-negative bacterial endotoxin represents a model for the shock seen in some patients with overwhelming infection. Though endotoxin has many seemingly unrelated effects, profound hypotension may suffice to limit the chances for survival.

This hypotension is probably mediated through neural as well as humoral agencies. There are profound effects on vascular smooth muscle, with constriction being particularly apparent in the early phase.

In the dog, cat, and probably in monkeys and man, there is a decreased venous return. This reduces cardiac output and is responsible for the



endotoxins ; shock

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.