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Abstracts |

The Role of the Thymus in Autoimmune Disease.

David W. Talmage, M.D.
Ann Intern Med. 1964;60(2_Part_1):329. doi:10.7326/0003-4819-60-2-329_1
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Approximately 10 years ago, Good began a renewal of interest in the function of the thymus with the observation of an unusually high association of thymoma with agammaglobulinemia. This was followed by Metcalf's demonstration of a lymphocyte-stimulating factor in extracts of the thymus and by the demonstration that mice thymectomized at birth were relatively immunologically incompetent and possessed few lymphocytes in their lymph organs. Due to the fact that thymectomy of adult animals led to little or no depression of immunologic responsiveness and due to the absence of lymph follicles in the thymus, it was at first thought that the


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