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Abstracts |

Immunological Mechanisms in Chronic Thyroiditis.

Noel R. Rose, Ph.D.
Ann Intern Med. 1964;60(2_Part_1):329. doi:10.7326/0003-4819-60-2-329_3
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A large majority of patients suffering from various forms of chronic thyroiditis develop one or more manifestations of auto-immune response: (1) precipitating auto-antibodies to thyroglobulin, (2) complement fixing antibodies to thyroid cell particulates, (3) cytotoxic antibodies to living thyroid cell cultures, or (4) dermal hypersensitivity to thyroid extract. Most adults with hypothyroidism show similar responses, as does smaller proportion of patients with hyperthyroidism or carcinoma of the thyroid. A few apparently normal individuals possess thyroid auto-antibodies, usually in low titer. Autologous thyroglobulin, injected under proper conditions, can produce autosensitivity in experimental animals, providing an avenue of study to the pathogenetic


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