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Abstracts |

An Analysis of Mechanisms of the Carcinoid Flush.

D. Joseph Demis, M.D.; and James G. Zimmer, M.D.
Ann Intern Med. 1964;60(2_Part_1):329-330. doi:10.7326/0003-4819-60-2-329_4
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Flushing has been accepted as an integral part of the carcinoid syndrome with its additional manifestations of diarrhea, right-sided valvular heart disease, and repiratory distress in the presence of metastatic carcinoid tumor. The transient flushes, usually involving the face, are among the most common manifestations and are certainly the most striking part of the syndrome. These cutaneous flushes have been classically described as patchy areas of erythema and cyanosis, though some have a purely erythematous flush. The flushes have been attributed to episodic release of serotonin from the tumor, and Schneckloth et al. (Circulation 16: 523, 1957) have produced the


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