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Factors Affecting Porphyrin-precursor Excretion by Patients with Acute Intermittent Porphyria.

Frederick H. Welland, M.D.; Emanuel Hellman, M.D., F.A.C.P.; Donald P. Tschudy, M.D.; and Annie Collins, B.S.
Ann Intern Med. 1964;60(2_Part_1):330-331. doi:10.7326/0003-4819-60-2-330_3
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An investigation of diet factors that affect the 24-hour urine porphobilinogen excretion in humans with acute intermittent porphyria was stimulated by the observation in this laboratory of a relationship between diet and porphobilinogenuria in experimental porphyria. The study was broadened when a relationship between attacks of acute intermittent porphyria and the menstrual cycle in human females was suspected.

Patients studied were hospitalized on a metabolic ward, where caloric intake and output as well as diet constitution were measured by standard methods. All patients had a positive Watson-Schwartz test, and 24-hour porphobilinogen excretion was measured by the dilution or column methods


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