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Abstracts |

Growth Hormone in Relation to Growth Disturbances.

Mary L. Parker, M.D.
Ann Intern Med. 1964;60(2_Part_1):331. doi:10.7326/0003-4819-60-2-331_2
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Pituitary dwarfism is suspected in individuals exhibiting immature skeletal proportions, retardation of linear growth, and comparable retardation of bone maturation. For several years, sulfation factor measurements have been employed in this laboratory in the evaluation of proportionate dwarfism. More recently, the metabolic responses (nitrogen retention and hydroxyproline excretion) to short-term administration of graded doses of human growth hormone, and the serum growth hormone level in response to insulin-induced hypoglycemia have shown promise in establishing the diagnosis of pituitary dwarfism.

Treatment of pituitary dwarfism with pituitary growth hormone has been strikingly successful in reducing normal growth rates. Bone maturation is stimulated


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