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Bio-assay of Human Serum Parathormone-like Activity.

Henry M. Lemon, M.D., F.A.C.P.; H. T. Lynch, M.D.; and M. J. Henn, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):331. doi:10.7326/0003-4819-60-2-331_3
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White Swiss mice pretreated with 3.0 ml of CaCl2 (16 mEq/liter) and MgCl2 (8 mEq/liter) in 0.9% saline respond to bovine parathyroid extract by a twofold or greater increase in urinary milliequivalent phosphorus/milliequivalent calcium in 4 hours, which follows a linear dose-response up to 1 to 2 USP units per mouse. Human serum, 0.1 ml, usually induces some increase in phosphorus/calcium excretion by mise, which we believe represents circulating parathyroid hormone (PTH), since (1) A fourfold increase in activity has been demonstrated in canine thyroid-parathyroid venous plasma compared to simultaneously sampled peripheral plasma. Thyroxin is inert. (2) Calcium gluconate infusions


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