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The Effect of Corticotropin and Adrenal Steroids on Adrenocortical and Pituitary Responsiveness.

Walter L. Palmer, M.D., F.A.C.P.; Peter I. Reed, M.D.; and Charles B. Clayman, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_1):331-332. doi:10.7326/0003-4819-60-2-331_4
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Clinical experience has shown that the effect of adrenocorticotrophic hormone (ACTH) and the adrenal hormones, while frequently dramatic, is nevertheless variable and often disappointing. Relatively little information is available on the adrenocortical and pituitary responsiveness in disease states and how this is influenced by both short and long-term treatment with ACTH and adrenal steroids. Our study has yielded preliminary data and warrants certain tentative conclusions.

Of the 20 patients studied, 13 had received ACTH only for periods of 2 weeks to 8½ years, 5 were on adrenal steroids for 3 days to 3¾ years and the remaining 2 patients had


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