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The Influence of Salicylates on Aspects of Carbohydrate and Lipid Metabolism.

Sheldon G. Gilgore, M.D.; Joseph J. Rupp, M.D. (Associate); and Lawrence W. Drew, M.D.
Ann Intern Med. 1964;60(2_Part_1):333. doi:10.7326/0003-4819-60-2-333_1
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Salicylates, like insulin and tolbutamide, effectively lower the elevated blood sugar levels of diabetics, but unlike insulin they do not significantly alter the blood glucose levels of normal subjects. In view of this important difference in mode of action it was decided to study not only changes in blood glucose but variations in the plasma nonesterified fatty acids (NEFA) after an intravenous infusion of sodium salicylate with the knowledge that insulin and the sulfonyl urea drugs produce a lowering of NEFA that parallels the lowering of the blood glucose. Five grams of sodium salicylate were infused intravenously into groups of


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