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Reduction of Toxicity of 5-Fluorouracil Cancer Chemotherapy.

Henry M. Lemon, M.D., F.A.C.P.; and P. J. Mozden, M.D.
Ann Intern Med. 1964;60(2_Part_1):333. doi:10.7326/0003-4819-60-2-333_2
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Toxicity that has handicapped the utilization of 5-fluorouracil for cancer chemotherapy has been greatly reduced by intravenous infusion of drug in 5% dextrose over an 8-hour period, permitting increased dosage and use with radiation therapy. This report evaluates over 100 slowly infused patients in whom moderate to severe toxicity occurred in only 6% with doses up to 25 g in as many days. Objective remissions attributed to drug alone were noted in 10%, with another 20% responding to combination therapy using X ray or steroids. Adenocarcinoma of the rectum and colon, breast, and ovary were most often responsive, with relief


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