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Familial Nephrogenic Diabetes Insipidus in a Female: A Study of the Effect of Hydrochlorathiazide.

Robert M. Wilson, M.D.; John W. Boylan, M.D., F.A.C.P.; and Thomas S. Bumbalo, M.D.
Ann Intern Med. 1964;60(2_Part_1):337. doi:10.7326/0003-4819-60-2-337_2
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A 13-year-old Negro girl with familial nephrogenic diabetes insipidus was treated with hydrochlorathiazide.

Polyuria and polydypsia had been present since infancy, and her father and paternal grandmother had the same symptoms. Physical examination showed a normal 155-lb girl. Daily urine volumes averaged 9 liters. Urinary osmolity ranged from 60 to 100 mOsm/liter. Volume and osmolality were unaffected by pitressin or the infusion of hypertonic saline. Water deprivation decreased urine volume with only slight increase in concentration.

Following a control period hydrochlorathiazide (50 mg, twice daily) caused a significant decrease in urine volume, free water clearance (CH2O) and creatinine clearance (Ccr).


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