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Diagnostic Significance of Serum and Urinary Protein Electrophoresis in Acute and Chronic Renal Disease.

Stanley H. Bernstein, M.D., F.A.C.P.; Jona Allerhand, M.D.; and James I. Berkman, M.D.
Ann Intern Med. 1964;60(2_Part_1):337-338. doi:10.7326/0003-4819-60-2-337_3
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Alterations in protein fractions, revealed by paper and immunoelectrophoresis, can be correlated with specific types of kidney disease. Sera and urine samples were analyzed in 25 patients in whom renal biopsy established an acute or chronic renal disease by means of cellulose-acetate paper electrophoresis and by immunoelectrophoresis. Antiserum was prepared by immunizing rabbits with pooled sera from patients with acute poststreptococcal glomerulonephritis (PSGN). Using these methods, it was possible to differentiate PSGN from acute nephritis occurring in patients without prior streptococcal infection. In both acute and chronic PSGN there were elevations in serum and urine gamma globulin which were not


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