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Abstracts |

Lysozymuria as an Indication of Renal Tubular Damage.

Darwin J. Prockop, M.D.; and Warren Davidson, M.D.
Ann Intern Med. 1964;60(2_Part_1):338. doi:10.7326/0003-4819-60-2-338_1
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The urinary excretion of the enzyme lysozyme has been observed previously in some patients with renal disease, but the significance of lysozymuria has not been established. In the present study, less than 4 µg/ml of urinary lysozyme actively (ULA) were found in 150 normal adults and patients without renal disease. By contrast, 37 of 59 patients with azotemia (blood urea nitrogen (BUN) > 20 mg/100 ml) excreted 5 to 120 µg/ml of ULA. Only 2 patients with BUN levels more than 30 mg/100 ml showed significant lysozymuria; both patients had nephrotic syndrome and died with severe uremia within 3 months.




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