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Rheumatic Fever in Children and Adolescents: A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae: I. Description of the Investigative Techniques and of the Population Studied

HARRISON F. WOOD, M.D.; RITA SIMPSON, B.A.; ALVAN R. FEINSTEIN, M.D.; ANGELO TARANTA, M.D.; ESTHER TURSKY, R.N.; and GENE STOLLERMAN, M.D., F.A.C.P.
Ann Intern Med. 1964;60(2_Part_2):6-17. doi:10.7326/0003-4819-60-2-6
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This report describes the selection and allocation of patients, the laboratory techniques, and certain related results in a long-term epidemiologic study of prophylaxis against streptococcal infections and recurrences of rheumatic fever. Begun by Irvington House on May 1, 1954, this study has tested three different antistreptococcal agents, with careful statistical design and control, in a population of 431 children and adolescents who had previously had one or more unequivocal attacks of rheumatic fever. Observation of the patients receiving these prophylactic agents was maintained for 5 calendar years and was continued for some of them through a sixth year, ending April

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