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Rheumatic Fever in Children and Adolescents: A Long-term Epidemiologic Study of Subsequent Prophylaxis, Streptococcal Infections, and Clinical Sequelae: V. Relation of the Rheumatic Fever Recurrence Rate per Streptococcal Infection to Pre-existing Clinical Features of the Patients

ANGELO TARANTA, M.D.; EDITH KLEINBERG, B.S.; ALVAN R. FEINSTEIN, M.D.; HARRISON F. WOOD, M.D.; ESTHER TURSKY, R.N.; and RITA SIMPSON, B.A.
Ann Intern Med. 1964;60(2_Part_2):58-67. doi:10.7326/0003-4819-60-2-58
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The rheumatic fever attack rate per streptococcal infection is quite constant and low, approximating 3 per cent in a number of epidemiologic reports (2). The only well-established exception occurs in patients who have already had rheumatic fever in whom the attack rate or, more specifically, the recurrence rate per infection is considerably higher. It was 16.5 per cent, for instance, in the population studied at the Irvington House Prophylaxis Clinic (3). In this population a positive relationship was found between the magnitude of the streptococcal antibody response and the rheumatic fever recurrence rate per infection (4, 5). This rate may also

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