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Secondary Aspergillosis

PAUL P. CARBONE, M.D.; SEYMOUR M. SABESIN, M.D.; HERSCHEL SIDRANSKY, M.D.; and EMIL FREI III, M.D.
Ann Intern Med. 1964;60(4):556-567. doi:10.7326/0003-4819-60-4-556
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The causative agents of most systemic and subcutaneous mycoses are saprophytes that are present in abundance in man's environment (1). One of these saprophytes is the genus Aspergillus whose members are particularly ubiquitous and survive under the poorest conditions of temperature, nourishment, and moisture (2). In 1897 Renon described in detail an occupational disease of wig makers and pigeon breeders due to Aspergillus (3). Since then, aspergillosis has become established as a clinical entity and has been the subject of several reviews (4-6). The tendency for aspergillosis to occur in patients with debilatating diseases such as histoplasmosis (7), tuberculosis (8),

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