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Cortisol Transport and Disappearance

W. R. BEISEL, M.D.; V. C. DIRAIMONDO, M.D.; and P. H. FORSHAM, M.D.
Ann Intern Med. 1964;60(4):641-652. doi:10.7326/0003-4819-60-4-641
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This excerpt has been provided in the absence of an abstract.

Reversible binding by plasma proteins appears fundamental in regulating the availability of circulating cortisol* for physiologic activity in tissues, for inactivation by the liver, or for excretion by the kidneys. Two plasma protein components are involved in binding nonmetabolized cortisol (1-3). At physiologic concentrations, plasma cortisol is bound predominantly by an alpha globulin termed corticosteroid-binding globulin (CBG) (1) or transcortin (3). This protein has a high binding affinity for cortisol, but is present only in low concentrations and so becomes rapidly saturated as the level of plasma cortisol is raised above normal. The other binding protein, plasma albumin

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