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Gluten and the Pathogenesis of Celiac Disease

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New York Hospital-Cornell Medical Center
New York, New York

Ann Intern Med. 1964;60(4):705-708. doi:10.7326/0003-4819-60-4-705
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It has been the universal experience of clinicians treating childhood and adult celiac disease that withdrawal of the cereal protein, gluten, from the diet may induce a clinical remission. Many recent reports describe the changes in intestinal histology and in absorptive function that result from this dietotherapy. In this issue of the ANNALS OF INTERNAL MEDICINE on page 581, Bolt, Parrish, French, and Pollard record the results of therapy in 13 patients. Their experience corresponds to that of other groups who have studied this disease (1-6).

The development of techniques for per oral biopsy of the small intestinal mucosa has


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