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A Compartmental Analysis of Single Intravenously Administered Doses of Tritiated Digoxin in Dogs.

Carlos E. Harrison Jr., M.D.; Robert O. Brandenburg, M.D.; Patrick A. Ongley, M.D.; Alan L. Orvis, M.D.; and Charles A. Owen Jr., M.D.
Ann Intern Med. 1964;60(4):709. doi:10.7326/0003-4819-60-4-709_1
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Tritiated digoxin was injected into dogs to study degradation of the glycoside and rates of distribution and excretion. In four dogs with biliary fistula, an average of 72.5 per cent of an intravenous dose appeared in the urine (57.5 per cent) and bile (15.0 per cent) within 4.5 days; of this, 60 per cent was digoxin, and 40 per cent was in the form of a metabolite. These were differentially extracted from urine and in bile were distinguished chromatographically by use of a methyl isobutyl ketone : isopropyl ether : butanol system.

In two dogs with bile fistula, an average


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