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Measurement of Valvular Regurgitation by Continuous Indicator Dilution.

Martin J. Frank, M.D.; Pablo Casanegra, M.D.; Manoucher Nadimi, M.D.; Angelo J. Migliori, M.D.; and Gilbert E. Levinson, M.D.
Ann Intern Med. 1964;60(4):711-712. doi:10.7326/0003-4819-60-4-711_3
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Studies of alterations in cardiac function produced by valvular regurgation require accurate quantification of regurgitant flow. Theoretically, valid measurements may be obtained by injecting an indicator distal to the incompetent valve and recording dilution curves simultaneously from the proximal cardiac chamber and a peripheral artery. However, measurements obtained with conventional sudden injections are often poorly reproducible or manifestly incorrect. The probability that mixing limitations at the injection site contribute to these unsatisfactory results suggested that a technique of continuous indicator infusion be substituted for sudden single injection. Studies were performed in 9 dogs and in 31 patients. In 56 determinations


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