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Abstracts |

New Observations on the Left Ventricular Contractile Response to Digitalis in Man.

A. M. Weissler, M.D.; and J. R. Snyder, M.D.
Ann Intern Med. 1964;60(4):712. doi:10.7326/0003-4819-60-4-712_1
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The administration of deslanoside to normal individuals is associated with a decrease in the duration of left ventricular ejection (LVET). This effect of the drug, which occurs in the absence of change in cardiac output, reflects its positive inotropic action and has been employed to study the temporal course and dose response relationships of deslanoside, ouabain and Lanoxin in man. The duration of LVET was derived from fast speed recordings of the externally derived carotid or subclavian arterial pulsation. With the intravenous administration of each of the above glycosides there is a prompt shortening in the LVET (corrected for heart


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