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Treatment of Chronic Atrial Fibrillation in Mitral Valvular Disease by Quinidine and by Direct Current Countershock: A Comparative Study.

John J. Kelly Jr., M.D., F.A.C.P.; Arthur Selzer, M.D., F.A.C.P.; Khodadad Keyani, M.D.; and William J. Kerth, M.D.
Ann Intern Med. 1964;60(4):714. doi:10.7326/0003-4819-60-4-714_2
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In a series of 108 patients, with mitral stenosis, mitral regurgitation, or both, who underwent mitral valvular repair, chronic atrial fibrillation was treated by quinidine (75 cases) and by direct current countershock (33 cases). Quinidine therapy was administered in the immediate postoperative period (beginning 5 to 10 days after the operation) resulting in the conversion of 25 patients (33%) to sinus rhythm. Eighteen patients who could not be reverted to sinus rhythm at this time returned for another trial of quinidine therapy 2 to 4 months after the operation. In 7 of 18 subjects, sinus rhythm was restored (39%). In


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