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Abstracts |

Estrogenic Hormone Therapy in Advanced Breast Cancer.

B. J. Kennedy, M.D., F.A.C.P.
Ann Intern Med. 1964;60(4):718. doi:10.7326/0003-4819-60-4-718_1
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Physiologic doses of estrogenic hormone have been demonstrated to stimulate breast cancer in young women, thereby providing a rationale for castration as a therapy in premenopausal women with advanced breast cancer. In postmenopausal women, estrogenic hormones have been effective in the treatment of advanced breast cancer, but it has been implied that the androgenic hormones are more effective. The latter have produced improvements in 21% of patients.

To test the effect of estrogenic hormones in premenopausal women with advanced breast cancer, massive doses (1,000 mg daily of stilbestrol) were administered. Improvement occurred in 17%. A randomized, comparative measurement of the


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