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A New, Rapid Test for Pheochromocytoma Based on the Urinary Assay of Normetanephrine, Metanephrine, and 3-Methoxy-4-hydroxyphenylglycol.

R. I. Wolf, M.D.; M. Mendlowitz, M.D., F.A.C.P.; J. Roboz, B.S.; and E. Gitlow, M.D., F.A.C.P.
Ann Intern Med. 1964;60(4):718. doi:10.7326/0003-4819-60-4-718_3
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Norepinephrine (NE) and epinephrine (E) are metabolized to a large degree, by O-methylation, to normetanephrine (NM) and metanephrine (M). NM and M may be metabolized to 3-methoxy-4-hydroxymandelic aldehyde (L) which may be either reduced to 3-methoxy-4-hydroxyphenylglycol (G) or oxidized to 3-methoxy-4-hydroxymandelic acid (VMA). A new, rapid, sensitive chromatoelectrophoretic urine test for pheochromocytoma is described, which is based on the quantitative urinary assay of NM, M, and G by chromatoelectrophoresis (barbital buffer, pH 8.6, ionic strength, 0.1, for 3.0 hr at 600 v) of a casual morning urine specimen collected without prior dietary or drug restrictions. Approximately 40 urine specimens may


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