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Serum and Urinary Amino Acids in Hyperuricemic and Normouricemic Subjects.

David Kaplan, M.D.; Stanley L. Wallace, M.D., F.A.C.P.; David Bernstein, M.D.; and David Halberstam, M.S.
Ann Intern Med. 1964;60(4):719-720. doi:10.7326/0003-4819-60-4-719_4
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On the supposition that (1) there is a renal defect in hyperuricemia, and that (2) based on evidence indicating that uric acid and some amino acids are handled similarly by the renal tubule, such a defect would not be specific for uric acid alone, we have studied the serum levels and renal clearances of amino acids in patients with hyperuricemia as compared to control patients. Renal function was evaluated with either creatinine or inulin and PAH clearances, and the studies performed after either an overnight fast or after 2 days on a 40 g protein diet. Six hyperuricemic and 14


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